PLANT MICROTUBULE INHIBITORS AGAINST TRYPANOSOMATIDS

被引：29

作者：

CHAN, MM

FONG, D

机构：

[1] Department of Biological Sciences, Rutgers, The State University of New Jersey, Piscataway

来源：

PARASITOLOGY TODAY | 1994年 / 10卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0169-4758(94)90182-1

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Trypanosomotid protozoa ore etiologic agents of several prevalent tropical diseases. Tubulins constitute 10% of the total proteins of these organisms. in addition, they are conserved within the Trypanosomatidae family but are different from that of the mammalian hosts. Since current chemotherapy has severe side effects, new compounds are urgently needed. The microtubular system provides a target for selective chemotherapy. Plant microtubule inhibitors, trifluralin and its analogues, inhibit Leishmania and Trypanosoma brucei, and Marion Chan and Dunne Fong here discuss the biosafety and potential for development of drug resistance to these compounds.

引用

页码：448 / 451

页数：4

共 45 条

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