EFFICIENT AND STEREOSELECTIVE SYNTHESIS OF J-104,118, A NOVEL, POTENT INHIBITOR OF SQUALENE SYNTHASE

被引：8

作者：

IWASAWA, Y

NONOSHITA, K

TOMIMOTO, K

机构：

[1] Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd., Tsukuba, 300-33

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 41期

关键词：

D O I：

10.1016/0040-4039(95)01542-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

J-104,118, a novel and potent inhibitor of squalene synthase, was synthesized stereoselectively. The chiral amine 1 was efficiently synthesized by Sharpless asymmetric dihydroxylation as a key reaction.

引用

页码：7459 / 7462

页数：4

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