The role of regulatory T cells in immune dysfunction during sepsis

被引：59

作者：

Cao, Chao ^{[1
]}

Ma, Tao ^{[2
]}

Chai, Yan-fen ^{[1
]}

Shou, Song-tao ^{[1
]}

机构：

[1] Tianjin Med Univ Gen Hosp, Emergency Dept, Tianjin 300052, Peoples R China

[2] Tianjin Med Univ, Gen Hosp, Dept Gen Surg, Tianjin 300052, Peoples R China

来源：

WORLD JOURNAL OF EMERGENCY MEDICINE | 2015年 / 6卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Regulatory T cells; Sepsis; Immune dysfunction;

D O I：

10.5847/wjem.j.1920-8642.2015.01.001

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

BACKGROUND: Although regulatory T cells (Tregs) are key to the maintenance of immunologic homeostasis and tolerance, little is known about Treg-mediated immunosuppression in the stage of sepsis. This article aimed to review the current literature on the role of Tregs in the pathophysiology of septic response, attempting to investigate the role of Tregs in immune dysfunction during sepsis. DATA SOURCES: A literature search was conducted in January 2014 using the China National Knowledge Infrastructure and PubMed. Articles on the role of Tregs in immune dysfunction during sepsis were identified. RESULTS: The identified articles indicated that Treg levels can be used for the assessment of the course of sepsis. The inhibition of Treg activity can promote the recovery of immune function. CONCLUSION: Since the mechanism of Tregs is complex during the sepsis, more studies are needed.

引用

页码：5 / 9

页数：5

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