EFFECT OF ANTIMICROBIAL AGENTS ON BINDING OF BILIRUBIN BY ALBUMIN

被引：24

作者：

MALAKAZAFIRIU, K

STRATES, BS

机构：

[1] Clinic of Pediatrics, the Laboratory of Pharmaceutical Chemistry, University of Thessaloniki

[2] A.H.E.P.A. Hospital, Thessaloniki

来源：

ACTA PAEDIATRICA SCANDINAVICA | 1969年 / 58卷 / 03期

关键词：

Albumin binding capacity; antimicrobial agents;

D O I：

10.1111/j.1651-2227.1969.tb04718.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The effect of antibiotics, on the albumin binding capacity was studied by adding various concentrations of each drug in a standard solution of crystalline human serum albumin 4 g/ 100 ml, according to method of Porter & Waters (8). We found significant depression (above 25 %) of binding capacity of the albumin after addition of the following drugs in concentrations reaching therapeutical blood levels: Novobiocin and Sulfonamides (Elkosin, Sulfexin, Gantrisin). Moderate depression (11‐25 %) was observed with the following drugs: Oxacillin, Ce‐phalothin and Rifamycin. Little or no decrease of the albumin binding capacity was found after the addition of the following drugs: Penicillin, Penetracin, Methi‐cillin (Staphcillin, Celbenin) Ampicillin, (Pen‐trexyl, Penbritin), Cloxacillin, Lincomycin, Cephaloridin, Streptomycin, Colimycin, Chloramphenicol succinate, Erythromycin, Tetra‐cyclin hydrochloride, Pyrolidynomethyl‐tetra‐cyclin and Oxytetracyclin. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：281 / +

页数：1

共 14 条

[1]

BOE RW, 1967, PEDIATRICS, V39, P194

[2]

HUGGINS C, 1949, CANCER RES, V9, P753

[3]

Malloy HT, 1937, J BIOL CHEM, V119, P481

[4] STUDIES ON PLASMA PROTEINS .77. PREPARATION AND PROPERTIES OF SERUM AND PLASMA PROTEINS .21. INTERACTIONS WITH BILIRUBIN [J].