RING-FLUORINATED PROSTAGLANDINS - TOTAL SYNTHESIS OF (+/-)-10-ALPHA-FLUOROPROSTAGLANDIN F2-ALPHA METHYL-ESTER

被引:24
作者
GRIECO, PA
WILLIAMS, E
SUGAHARA, T
机构
[1] Department of Chemistry, University of Pittsburgh, Pittsburgh
关键词
D O I
10.1021/jo01327a034
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The total synthesis of 10α-fluoroprostaglandin F2α methyl ester (1) is described. Introduction of fluorine at C(10) involved treatment of triflate 15 with tetra-n-butylammonium fluoride in refluxing tetrahydrofuran. © 1979, American Chemical Society. All rights reserved.
引用
收藏
页码:2194 / 2199
页数:6
相关论文
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