ALTERATIONS IN ACETYLCHOLINE-INDUCED STIMULATION OF INOSITOL PHOSPHOLIPID HYDROLYSIS IN THE DORSAL HIPPOCAMPUS OF KINDLED RATS

被引:5
作者
ZHANG, WQ
TANDON, P
SOBOTKA, TJ
HONG, JS
TILSON, HA
机构
[1] NIEHS,MOLEC & INTEGRAT NEUROSCI LAB,POB 12233,RES TRIANGLE PK,NC 27709
[2] US FDA,WASHINGTON,DC 20204
关键词
Acetylcholine; Excitatory amino acid; Hippocampus; Inositolphosphate; Kindling;
D O I
10.1016/0304-3940(90)90248-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Agonist-induced turnover or release of inositolphosphates (IP) was studied in the dorsal and the ventral hippocampus 24 h, 1 month, and 3 months after the last electrical stimulus of kindled rats. A significant increase in acetylcholine (ACh)-stimulated IP turnover was observed in dorsal, but not ventral, hippocampus 24 h and 1 month after the last electrical stimulus. However, this effect was not evident 3 months after kindling. The excitatory amino acids (quisqualic acid and ibotenic acid) at the concentrations used, however, failed to produce any change in receptor-stimulated release or turnover of IP. Thus the changes in ACh-induced IP release, although long-term, are not permanent and do not appear to be related to the neurobiological alterations associated with the long-term maintenance of the kindling phenomenon. © 1990.
引用
收藏
页码:57 / 60
页数:4
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