STUDY OF THE INTERACTION OF CADMIUM WITH MEMBRANE-BOUND SUCCINATE-DEHYDROGENASE

被引：42

作者：

JAY, D

ZAMORANO, R

MUNOZ, E

GLEASON, R

BOLDU, JL

机构：

[1] NATL POLYTECH INST,ESCUELA SUPER FIS & MATEMAT,DEPT FIS,MEXICO CITY 14,DF,MEXICO

[2] NATL AUTONOMOUS UNIV MEXICO,INST FIS,MEXICO CITY 04510,DF,MEXICO

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1991年 / 23卷 / 02期

关键词：

MITOCHONDRIA; PHOSPHORYLATING ELECTRON TRANSPORT PARTICLES; SUCCINATE DEHYDROGENASE; HEART SUCCINATE DEHYDROGENASE; RESPIRATORY CHAIN; CADMIUM; SUBSTRATE-BINDING SITE;

D O I：

10.1007/BF00762229

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Cadmium ions inhibit membrane-bound succinate dehydrogenase with a second-order rate constant of 10.42 mM-1 s-1 at pH 7.35 and 25-degrees-C. Succinate and malonate protect the enzyme against cadmium ion inhibition. The protection pattern exerted by succinate and malonate suggests that the group modified by cadmium is located at the active site. The pH curve of inactivation by Cd2+ indicates the involvement of an amino acid residue with pKa of 7.23.

引用

页码：381 / 389

页数：9

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[2]

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