CHRONIC ETHANOL FEEDING PRODUCES AN INCREASE IN MUSCARINIC CHOLINERGIC RECEPTORS IN MOUSE-BRAIN

被引：100

作者：

TABAKOFF, B

MUNOZMARCUS, M

FIELDS, JZ

机构：

[1] UNIV ILLINOIS,MED CTR,DEPT PHYSIOL & BIOPHYS,CHICAGO,IL 60612

[2] UNIV HLTH SCI,CHICAGO MED SCH,DEPT PHARMACOL,CHICAGO,IL 60612

来源：

LIFE SCIENCES | 1979年 / 25卷 / 26期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0024-3205(79)90089-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chronic ethanol administration (seven days) to mice produces physical dependence while subsequent withdrawal produces seizures and convulsions, especially during the first 24 hours. It is known that ethanol can inhibit brain acetylcholine (ACh) release. Our present study suggests that hippocampal (+25%) and cortical (+14%), but not striatal neurons, can respond to the ethanol-induced reduction in neurotransmitter (ACh) availability by increasing the number of muscarinic cholinergic receptors. It is possible that these supersensitive neurons are involved in the CNS hyperexcitability induced by withdrawal from chronic ethanol. © 1979.

引用

页码：2173 / 2180

页数：8

共 22 条

[1] KINDLING AS A MODEL FOR ALCOHOL WITHDRAWAL SYNDROMES [J].