SELECTIVE TRANSFORMATION OF NITRILES INTO AMIDES AND CARBOXYLIC-ACIDS BY AN IMMOBILIZED NITRILASE

被引：52

作者：

KLEMPIER, N

DERAADT, A

FABER, K

GRIENG, H

机构：

[1] Christian Doppler Laboratory for the Chemistry of Chiral Compounds, the Institute of Organic Chemistry, Graz University of Technology, A-8010 Graz

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(00)92623-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using an immobilized nitrilase from Rhodococcus sp. mild and selective hydrolysis of nitriles can be achieved even in the presence of acid or base sensitive groups under neutral conditions. This method is applicable to a broad range of substrates as exemplified by aliphatic, alicyclic, heterocyclic and carbohydrate type nitriles.

引用

页码：341 / 344

页数：4

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