ROLES OF RENAL AND VASCULAR RENIN IN SPONTANEOUS HYPERTENSION AND SWITCHING OF THE MECHANISM UPON NEPHRECTOMY - LACK OF HYPOTENSIVE EFFECTS OF INHIBITION OF RENIN, CONVERTING ENZYME, AND ANGIOTENSIN-II RECEPTOR BLOCKER AFTER BILATERAL-NEPHRECTOMY

被引：42

作者：

INAGAMI, T

MURAKAMI, T

HIGUCHI, K

NAKAJO, S

机构：

[1] Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 01期

关键词：

VASCULAR RENIN; SPONTANEOUS HYPERTENSION; NEPHRECTOMY; ANTIRENIN ANTIBODY; ANGIOTENSIN CONVERTING ENZYME INHIBITORS; ANGIOTENSIN-II RECEPTOR ANTAGONIST; ANGIOTENSINOGEN INTRACELLULAR RENIN; EXTRACELLULAR RENIN;

D O I：

10.1093/ajh/4.1.15S

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Inhibitors of angiotensin converting enzyme, renin, and the angiotensin II (Ang II) receptor lower the blood pressure of spontaneously hypertensive rats (SHR) used as a model of essential hypertension. Since their plasma renin levels were normal or subnormal, renin in the vascular tissue was considered to play a key role in the maintenance of the hypertension. To clarify the source and localization of renin in SHR, antirenin antibodies, the converting enzyme inhibitors delapril, enalapril, and the Ang II receptor antagonist DuP 753 were administered to intact and bilaterally nephrectomized SHR and their normotensive controls. The efficient hypotensive action of the renin antibody indicated that renin of renal origin is a dominant factor. Gradual but complete disappearance of antihypertensive action of these inhibitors of the renin-angiotensin system upon bilateral nephrectomy indicated the importance of membrane-associated renin of the renal origin and angiotensin converting enzyme in the maintenance of the spontaneous hypertension.

引用

页码：S15 / S22

页数：8

共 51 条

[1] Gavras H., Brunner H.K., Turin G.A., Et al., Antihypertensive effect of the oral administration of the angiotensin converting enzyme inhibitor SQ 14255 in man, N Engl J Med, 298, pp. 991-992, (1978)
[2] Laffan R.J., Goldberg M.E., High J.P., Et al., Antihypertensive activity in rats of SQ 14255, an orally active inhibitor of angiotensin converting enzyme, J Pharmacol Exp Ther, 204, pp. 281-288, (1978)
[3] Muirhead E.E., Prewitt R.L., Brooes B., Brosius W.L., Antihypertensive action of the orally active converting enzyme inhibitor (SQ 14255) in spontaneously hypertensive rats, Circ Res, 43, (1978)
[4] Assad M.M., Antonaccio M.J., Vascular wall renin in spontaneously hypertensive rats: Potential relevance to hypertension maintenance and antihypertensive effect of captopril, Hypertension, 4, pp. 487-493, (1982)
[5] Gould A.B., Skeggs L.T., Kahn J.R., Presence of renin activity in vascular walls, J Exp Med, 119, pp. 389-399, (1964)
[6] Rosenthal J., Boucher J., Roho-Ortega J.M., Genest J., Renin activity in aortic tissue of rats, Am J Physiol Pharmacol, 47, pp. 53-56, (1969)
[7] Barrett J.D., Eggena P., Sambhi M.P., Partial characterization of aortic renin in the spontaneously hypertensive rat and its interrelationship with plasma renin, blood pressure and sodium balance, Clin Sci Mol Med, 55, pp. 261-270, (1978)
[8] Basso N., Taquini A.C., Effects of bilateral nephrectomy on the renin activity of blood vessel walls, Acta Physiol La-Tinoamerica, 46, pp. 12-14, (1974)
[9] Reid I.A., Is there a brain renin-angiotensin system in the brain?, Circ Res, 41, pp. 147-153, (1977)
[10] Hackenthal E., Hackenthal R., Hilgenfeldt U., Isorenin, pseudorenin, cathepsin D and renin. A comparative enzymic study of angiotensin forming enzymes, Biochem Biophys Acta, 522, pp. 561-573, (1978)

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