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STIMULATION OF ERYTHROID-CELLS ADENYLATE-CYCLASE BY SOLUBLE FACTORS

被引：13
作者：
BEAUMONT, C
PIAU, JP
FISCHER, S
DELAUNAY, J
SCHAPIRA, G
机构：
[1] CTR HOSP UNIV COCHIN,INST PATHOL MOLEC,F-75014 PARIS,FRANCE
[2] UNIV PARIS 5,INSERM,U15,CNRS LAB 85,F-75270 PARIS 06,FRANCE
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 04期
关键词：
D O I：
10.1016/0006-291X(79)91201-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Soluble factors obtained from human, rat and rabbit erythroid cell lysates are capable to stimulate basal and hormone activated adenylate cyclase of erythroid cell membranes from homologous sources. Extensive dialysis and removal of hemoglobin from the soluble factors do not modify their activity. Human erythrocyte soluble factors stimulate the human reticulocyte enzyme. Nevertheless human erythrocyte adenylate cyclase is not stimulated by either of the soluble factors. The presence of active soluble factors in human erythrocytes where the adenylate cyclase is no longer sensitive to these factors, as well as to guanylnucleotides or protaglandins, indicates that the enzyme has been altered during the maturation processes. © 1979.
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页码：1250 / 1257
页数：8
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