PATHOGENIC FACTORS IN INFLAMMATORY BOWEL-DISEASE .2. CROHNS-DISEASE

被引：14

作者：

PAVLI, P ^{[1
]}

GIBSON, PR ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV CLIN SCI,CANBERRA,ACT 2601,AUSTRALIA

来源：

DIGESTIVE DISEASES | 1992年 / 10卷 / 02期

关键词：

CROHNS DISEASE; INFLAMMATORY BOWEL DISEASE; PATHOGENESIS; ETIOLOGY; ANTIGEN PROCESSING; MACROPHAGES; T-CELLS; IMMUNE ACTIVATION; INFLAMMATION;

D O I：

10.1159/000171346

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Clues from patient and experimental animal studies suggest that events occurring early in the pathogenesis of Crohn's disease are related to an inability of the immune system to eradicate one or a number of luminal antigens resulting in persistent T cell and macrophage activation. Whether the primary abnormality rests with the nature of the luminal antigen, disturbances of antigen uptake by the mucosa, antigen handling by macrophages, or macrophage-T cell interactions remains unresolved. Given the heterogeneity of clinical presentations and experimental data. Crohn's disease may be a group of disorders associated with a number of primary defects.

引用

页码：72 / 84

页数：13