BIP (GRP78), AN ESSENTIAL HSP70 RESIDENT PROTEIN IN THE ENDOPLASMIC-RETICULUM

被引：198

作者：

HAAS, IG

机构：

[1] Institut für Biochemie der Universität Heidelberg, Heidelberg, D-69120

来源：

EXPERIENTIA | 1994年 / 50卷 / 11-12期

关键词：

ER-TRANSLOCATION; FOLDING AND ASSEMBLY OF POLYPEPTIDE CHAINS; HSP70; STRUCTURE; ER-DEGRADATION;

D O I：

10.1007/BF01923455

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BiP is a constitutively-expressed resident protein of the endoplasmic reticulum (ER) of all eucaryotic cells, and belongs to the highly conserved hsp70 protein family. In the ER, BiP is involved in polypeptide translocation, protein folding and presumably protein degradation as well. These functions are essential to cell viability, as has been shown for yeast. In this review, I will summarize the structural features of hsp70 proteins and focus on those experiments which revealed the biological function of BiP.

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页码：1012 / 1020

页数：9

相关论文

共 93 条

[1] INTERACTION OF HSP-70 WITH NEWLY SYNTHESIZED PROTEINS - IMPLICATIONS FOR PROTEIN FOLDING AND ASSEMBLY [J].

BECKMANN, RP ;

MIZZEN, LA ;

WELCH, WJ .

SCIENCE, 1990, 248 (4957) :850-854

[2] AFFINITY PANNING OF A LIBRARY OF PEPTIDES DISPLAYED ON BACTERIOPHAGES REVEALS THE BINDING-SPECIFICITY OF BIP [J].

BLONDELGUINDI, S ;

CWIRLA, SE ;

DOWER, WJ ;

LIPSHUTZ, RJ ;

SPRANG, SR ;

SAMBROOK, JF ;

GETHING, MJH .

CELL, 1993, 75 (04) :717-728

[3] POSTTRANSLATIONAL ASSOCIATION OF IMMUNOGLOBULIN HEAVY-CHAIN BINDING-PROTEIN WITH NASCENT HEAVY-CHAINS IN NONSECRETING AND SECRETING HYBRIDOMAS [J].

BOLE, DG ;

HENDERSHOT, LM ;

KEARNEY, JF .

JOURNAL OF CELL BIOLOGY, 1986, 102 (05) :1558-1566

[4] AN ATPASE DOMAIN COMMON TO PROKARYOTIC CELL-CYCLE PROTEINS, SUGAR KINASES, ACTIN, AND HSP70 HEAT-SHOCK PROTEINS [J].

BORK, P ;

SANDER, C ;

VALENCIA, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) :7290-7294

[5] ROLE OF ATP AND DISULFIDE BONDS DURING PROTEIN FOLDING IN THE ENDOPLASMIC-RETICULUM [J].

BRAAKMAN, I ;

HELENIUS, J ;

HELENIUS, A .

NATURE, 1992, 356 (6366) :260-262

[6] MANIPULATING DISULFIDE BOND FORMATION AND PROTEIN FOLDING IN THE ENDOPLASMIC-RETICULUM [J].

BRAAKMAN, I ;

HELENIUS, J ;

HELENIUS, A .

EMBO JOURNAL, 1992, 11 (05) :1717-1722

[7] DISSOCIATION OF CLATHRIN COATS COUPLED TO THE HYDROLYSIS OF ATP - ROLE OF AN UNCOATING ATPASE [J].

BRAELL, WA ;

SCHLOSSMAN, DM ;

SCHMID, SL ;

ROTHMAN, JE .

JOURNAL OF CELL BIOLOGY, 1984, 99 (02) :734-741

[8] RECONSTITUTION OF PROTEIN TRANSLOCATION FROM SOLUBILIZED YEAST MEMBRANES REVEALS TOPOLOGICALLY DISTINCT ROLES FOR BIP AND CYTOSOLIC HSC70 [J].

BRODSKY, JL ;

HAMAMOTO, S ;

FELDHEIM, D ;

SCHEKMAN, R .

JOURNAL OF CELL BIOLOGY, 1993, 120 (01) :95-102

[9] A SEC63P-BIP COMPLEX FROM YEAST IS REQUIRED FOR PROTEIN TRANSLOCATION IN A RECONSTITUTED PROTEOLIPOSOME [J].

BRODSKY, JL ;

SCHEKMAN, R .

JOURNAL OF CELL BIOLOGY, 1993, 123 (06) :1355-1363

[10] DEFECTIVE CO-TRANSLATIONAL FORMATION OF DISULFIDE BONDS IN PROTEIN DISULFIDE-ISOMERASE-DEFICIENT MICROSOMES [J].

BULLEID, NJ ;

FREEDMAN, RB .

NATURE, 1988, 335 (6191) :649-651

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