STANDARDIZED MICROTITER ASSAY FOR DETERMINATION OF SYNCYTIUM-INDUCING PHENOTYPES OF CLINICAL HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES

被引：81

作者：

JAPOUR, AJ

FISCUS, SA

ARDUINO, JM

MAYERS, DL

REICHELDERFER, PS

KURITZKES, DR

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02215

[2] UNIV N CAROLINA,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC 27599

[3] WALTER REED ARMY INST RES,DEPT HIV DRUGS & GENE THERAPY,ROCKVILLE,MD 20850

[4] NIAID,DIV AIDS,BETHESDA,MD 20892

[5] UNIV COLORADO,HLTH SCI CTR,DIV INFECT DIS,DENVER,CO 80262

[6] VET AFFAIRS MED CTR,DENVER,CO 80262

[7] USN,INST MED RES,ROCKVILLE,MD

[8] HARVARD UNIV,SCH PUBL HLTH,CTR STAT DATA ANAL,BOSTON,MA 02215

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1994年 / 32卷 / 09期

关键词：

D O I：

10.1128/JCM.32.9.2291-2294.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A standardized assay in 96-well microtiter plates for syncytium-inducing (SI) human immunodeficiency virus type 1 phenotype detection using MT-2 cells has been developed. SI variants were found in 67% of the patients with advanced human immunodeficiency virus disease. The occurrence of the SI phenotype increased with lower CD4(+) counts. There was no association between p24 antigenemia and the SI phenotype.

引用

页码：2291 / 2294

页数：4

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