DIRECT SYNTHESIS OF 3-(FLUOROALKYL)PYRAZOLES FROM POLYFLUOROALKYL ALDEHYDES

被引：40

作者：

TANG, XQ ^{[1
]}

HU, CM ^{[1
]}

机构：

[1] CHINESE ACAD SCI,SHANGHAI INST ORGAN CHEM,SHANGHAI 200032,PEOPLES R CHINA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 15期

关键词：

D O I：

10.1039/p19940002161

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-(Fluoroalkyl) pyrazoles 3 have been synthesized in excellent yields by reaction of various fluoroalkyl aldehydes with NH2NH2.HOAc under mild conditions. It appears that the reaction involves the formation of a hydrazone intermediate, followed by elimination of hydrogen halide and intramolecular nucleophilic addition. A practical one-pot synthesis of 3-(fluoroalkyl)pyrazoles from polyfluoroalkyl iodides 1 has also been developed.

引用

页码：2161 / 2163

页数：3

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