INTERLEUKIN-6 AND INTERLEUKIN-8 EXTRACTION DURING CONTINUOUS VENOVENOUS HEMODIAFILTRATION IN SEPTIC ACUTE-RENAL-FAILURE

被引：54

作者：

BELLOMO, R

TIPPING, P

BOYCE, N

机构：

[1] Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168

来源：

RENAL FAILURE | 1995年 / 17卷 / 04期

关键词：

ACUTE RENAL FAILURE; CYTOKINES; HEMODIALYSIS; HEMOFILTRATION; INTERLEUKIN-6; INTERLEUKIN-8; SEPSIS; SHOCK;

D O I：

10.3109/08860229509037609

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To determine whether continuous venovenous hemodiafiltration (CVVHD) is associated with the extraction of interleukin-6 (IL-6) and interleukin-8 (IL-8) from the circulation of critically ill patients with septic acute renal failure. To quantitate their clearance and assess arty possible effect of CVVHD on these cytokines' serum concentrations, Design: Prospective controlled study of IL-6 and IL-8 removal by CVVHD in patients with septic acute renal failure. Setting: Intensive care unit of a tertiary institution. Patients: Ten critically ill patients with sepsis, acute renal failure, and multiorgan failure A control group of five patients experiencing an acute illness while undergoing chronic hemodialysis. Interventions: Collection of blood samples before CVVHD. Simultaneous collection of prefilter blood and ultradiafiltrate after 4 and 24 h of treatment IL-8 concentrations were measured in blood and ultradiafiltrate. Their clearances and daily extractions were calculated. Measurements and Main Results: IL-6 and IL-8 were detected in the blood of all patients with septic acute renal failure prior to CVVHD. The median IL-6 blood level was 103 pg/mL (range: 19 to 900) and the median IL-8 blood level was 200 (range: 32 to 2925). Both cytokines were cleared by the hemofilter during CVVHD. The median hemofilter clearance of IL-6 were 1.99 L/day (range: 0 to 8.5) and the median clearance of IL-8 was 3.95 L/day (range: 0.31 to 42.8). These blood levels and clearances resulted in median daily extraction rates of 194 ng of lL-6 (range: 0 to 9031) and of 915 ng of IL-8 (range 47.5 to 3562). Control patients had negligible amounts of either IL-6 or IL-8 in their ultrafiltrate. The rate of extraction for IL-6 correlated with its blood levels (p < 0.0001). This was not true for IL-8. A correlation between IL-6 levels and the patients' white cell counts was found after 24 h of hemofiltration. Conclusions: CVVHD is associated with the extraction of IL-6 and IL-8 from the circulation of patients with septic multiorgan and renal failure. The biological significance of such extraction is undetermined but such cytokine removal highlights the complexity of the effect of continuous hemofiltration on the soluble mediators of inflammation activated during human sepsis.

引用

页码：457 / 466

页数：10

共 25 条

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