CYTOKINE STIMULATION DURING SALMONELLA-TYPHIMURIUM SEPSIS IN ITY(S) MICE

被引：18

作者：

JOTWANI, R

TANAKA, Y

WATANABE, K

TANAKA, K

KATO, N

UENO, K

机构：

[1] GIFU UNIV,SCH MED,INST ANAEROB BACTERIOL,GIFU 500,JAPAN

[2] GIFU COLL MED TECHNOL,GIFU 50132,JAPAN

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1995年 / 42卷 / 05期

关键词：

D O I：

10.1099/00222615-42-5-348

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cytokine production was measured in mice during Salmonella typhimurium sepsis and intoxication. In mice given live S. typhimurium (10 cfu/mouse), by intra-peritoneal injection, serum levels of tumour necrosis factor (TNF)-alpha and interleukin-6 increased steadily from day 1 until day 4. Interferon-gamma levels showed a transient peak on day 3. Interleukin-1-alpha levels were very low. There were high bacterial counts in the livers at day 3 and deaths occurred from day 4 onwards. Intraperitoneal injection of lipopolysaccharide or heat-killed bacteria also induced all of the cytokines, but their time of appearance and levels varied greatly. Cytokine induction by heat-killed bacteria was more marked. Endotoxaemia decreased with time during intoxication and increased during sepsis. Bioactive TNF, as measured by a cytotoxicity assay, was found only in mice given heat-killed bacteria.

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页码：348 / 352

页数：5

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