PARASEXUAL CYCLE IN CULTIVATED HUMAN SOMATIC CELLS

被引：66

作者：

MARTIN, GM

SPRAGUE, CA

机构：

[1] Department of Pathology, University of Washington, School of Medicine, Seattle

来源：

SCIENCE | 1969年 / 166卷 / 3906期

关键词：

D O I：

10.1126/science.166.3906.761

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Somatic segregation for three different autosomes was demonstrated in two strains of human diploid fibroblasts derived front subjects known to be heterozygous for chromosomal variants. Recombinant diploid cells appeared within cultures of tetraploid clones isolated from mass cultures. Tetraploid cells regularly occur in mass cultures and within clones of diploid cells. Such a parasexual cycle (2n → 4n → 2n), with recombination of entire linkage groups, could form the basis of a beginning formal genetic analysis in man.

引用

页码：761 / &

共 17 条

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