DIRECT ACTIVATION OF GTP-BINDING REGULATORY PROTEINS (G-PROTEINS) BY SUBSTANCE-P AND COMPOUND 48/80

被引:286
作者
MOUSLI, M
BRONNER, C
LANDRY, Y
BOCKAERT, J
ROUOT, B
机构
[1] CTR CNRS INSERM PHARMACOL ENDOCRINOL, RUE CARDONILLE, F-34094 MONTPELLIER, FRANCE
[2] UNIV LOUIS PASTEUR STRASBOURG 1, NEUROIMMUNOPHARMACOL LAB, ILLKIRCH GRAFFENSTADEN, FRANCE
来源
FEBS LETTERS | 1990年 / 259卷 / 02期
关键词
Compound; 48; 80; G-protein; Mast cell; Mastoparan; Substance P;
D O I
10.1016/0014-5793(90)80023-C
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The neuropeptide substance P and the polyamine compound 48 80, both known to activate mast cell secretory processes, increased the rate of GTPγS binding to G-proteins purified from calf brain (Go/Gi mixture). The GTPase activity of G-proteins was also increased by substance P and compound 48 80 in a dose-dependent and Mg2+-dependent way. These effects were similar to those of the wasp venom peptide rnastoparan, another histamine releaser of rat peritoneal and human skin mast cells. This suggests that the secretory property of compound 48 80 and substance P is not due to a receptor-mediated process but, like mastoparan, results from a direct activation of G-proteins. © 1990.
引用
收藏
页码:260 / 262
页数:3
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