IDENTIFICATION OF PARA-ACETAMIDOBENZOATE AS A FOLATE DEGRADATION PRODUCT IN RAT URINE

被引:30
作者
CONNOR, MJ
PHEASANT, AE
BLAIR, JA
机构
关键词
D O I
10.1042/bj1780795
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Within 48 h of administration of radiolabelled 10-formylfolate, folic acid and the polyglutamate derivative 10-formylfolate tetraglutamate to the rat, fragmentation products are found in the urine. The major catabolite was identified as p-acetamidobenzoate by chromatography and reverse isotope-dilution analysis.
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页码:795 / 797
页数:3
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