TRISOMY-21 IN TRANSIENT MYELOPROLIFERATIVE DISORDER

被引：29

作者：

FAED, MJW

ROBERTSON, J

TODD, AS

SIVAKUMARAN, M

TARNOWMORDI, WO

机构：

[1] UNIV DUNDEE,DEPT PATHOL,HUMAN GENET LAB,DUNDEE DD1 4HN,SCOTLAND

[2] UNIV DUNDEE,DEPT HAEMATOL,DUNDEE DD1 4HN,SCOTLAND

[3] UNIV DUNDEE,DEPT CHILD HLTH,DUNDEE DD1 4HN,SCOTLAND

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 48卷 / 02期

关键词：

D O I：

10.1016/0165-4608(90)90129-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transient leukemia in phenotypically normal children is rare. A newborn child in whom fever and tachypnea developed at age 2 days had a white blood cell count of 20.1 × 109/L and many abnormal blast cells. Chromosome analysis of spontaneously dividing cells from the blood showed these to have trisomy 21, and 80% of cells in the marrow were also trisomic. No trisomic cells were present in skin fibroblast cultures. At age 6 months, at which time the blood film appeared normal, trisomic cells were no longer present. © 1990.

引用

页码：259 / 264

页数：6

共 19 条

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