DIOLEPOXIDES - KEY TO HYDROCARBON CARCINOGENESIS

被引：6

作者：

OSBORNE, MR

机构：

[1] M. R. Osborne is at the Institute of Cancer Research, Pollards Wood Research Station, Bucks HP8 4SP, Chalfont St Giles

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1979年 / 4卷 / 09期

关键词：

D O I：

10.1016/0968-0004(79)90084-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrocarbons such as benzopyrene are metabolized to diolepoxides which react avidly with nucleic acids. Study of this reaction and its consequences may explain how these hydrocarbons can cause cancer. © 1979.

引用

页码：213 / 215

页数：3

共 17 条

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[3]

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[5] MULTIPLE REGIONS OF METABOLIC ACTIVATION OF CARCINOGENIC HYDROCARBONS [J].

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NATURE, 1978, 273 (5663) :566-568

[6]

HECHT SS, 1978, CANCER RES, V38, P2191

[7] IDENTIFICATION OF 3-METHYLCHOLANTHRENE-9,10-DIHYDRODIOL AS AN INTERMEDIATE IN BINDING OF 3-METHYLCHOLANTHRENE TO DNA IN CELLS IN CULTURE [J].

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[8]

LEHR RE, 1978, CARCINOGENESIS, V3, P231

[9] EXCEPTIONAL MUTAGENICITY OF A BENZO[ALPHA]PYRENE DIOL EPOXIDE IN CULTURED MAMMALIAN-CELLS [J].

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NATURE, 1976, 261 (5555) :52-54

[10] REACTION OF TRANS-7,8-DIHYDROXY-ANTI-9,10-EPOXY-7,8,9,10-TETRAHYDROBENZO(A)PYRENE WITH DNA INVOLVES ATTACK AT N-7-POSITION OF GUANINE MOIETIES [J].

OSBORNE, MR ;

HARVEY, RG ;

BROOKES, P .

CHEMICO-BIOLOGICAL INTERACTIONS, 1978, 20 (01) :123-130

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