C-11 SCH 39166, A SELECTIVE LIGAND FOR VISUALIZATION OF DOPAMINE-D1 RECEPTOR-BINDING IN THE MONKEY BRAIN USING PET

被引：33

作者：

SEDVALL, G ^{[1
]}

FARDE, L ^{[1
]}

BARNETT, A ^{[1
]}

HALL, H ^{[1
]}

HALLDIN, C ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP,BLOOMFIELD,NJ 07003

来源：

PSYCHOPHARMACOLOGY | 1991年 / 103卷 / 02期

关键词：

D1-DOPAMINE RECEPTORS; POSITRON EMISSION TOMOGRAPHY; MONKEY BRAIN; DOPAMINE RECEPTOR ANTAGONIST; ANTIPSYCHOTIC DRUGS;

D O I：

10.1007/BF02244195

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The new selective D1-dopamine receptor antagonist SCH 39166 was labelled with the positron emitting isotope C-11 and used as ligand for visualization of dopamine-D1 receptor binding in Cynomologus monkeys by PET. After intravenous administration of the ligand a marked uptake of radioactivity was recorded in the D1-dopamine receptor-rich striatum and neocortex but not in the dopamine receptor-poor cerebellum. The uptake of radioactivity in striatum and neocortex was markedly displaced after the intravenous injection of a high dose of the D1-dopamine receptor antagonist SCH 23390 but not after the 5-HT2 receptor antagonist ketanserine. C-11-SCH 39166 should be a useful tool to explore D1-dopamine receptor characteristics in the living human brain by PET.

引用

页码：150 / 153

页数：4

共 14 条

[1]

BARNET A, 1986, NEW YORK TIMES BK R, P15

[2] CHARACTERIZATION OF THE BINDING OF H-3-SCH 23390, A SELECTIVE D-1 RECEPTOR ANTAGONIST LIGAND, IN RAT STRIATUM [J].