BOOSTER RESPONSE TO RECOMBINANT YEAST-DERIVED HEPATITIS-B VACCINE IN VACCINEES WHOSE ANTI-HBS RESPONSES WERE INITIALLY ELICITED BY A PLASMA-DERIVED VACCINE

被引：8

作者：

CHAN, CY ^{[1
]}

LEE, SD ^{[1
]}

TSAI, YT ^{[1
]}

LO, KJ ^{[1
]}

机构：

[1] VET GEN HOSP,DEPT MED,DIV GASTROENTEROL,TAIPEI 11217,TAIWAN

来源：

VACCINE | 1991年 / 9卷 / 10期

关键词：

BOOSTER RESPONSE; PLASMA-DERIVED HEPATITIS-B VACCINE; RECOMBINANT YEAST-DERIVED VACCINE;

D O I：

10.1016/0264-410X(91)90294-G

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One hundred and eight primary school students who had been vaccinated with three doses of a plasma-derived hepatitis B vaccine were randomly divided into two groups, to receive a booster dose of either the same vaccine or of a recombinant yeast-derived vaccine. The pre-booster anti-hepatitis B surface antigen (HBs) geometric mean titres (GMT) were similar in both groups (281.8 mIU ml-1 versus 295.1 mIU ml-1, p > 0.5). One month after booster vaccination, all the vaccinees in both groups had a marked elevation in their anti-HBs titres, the anti-HBs GMT in group 1 and group 2 being 19 952.6 and 51 286.1 mIU ml-1 (p < 0.05), respectively. In conclusion, the recombinant yeast-derived hepatitis B vaccine was able to elicit an excellent booster response in vaccinees who had originally received a plasma-derived vaccine.

引用

页码：765 / 767

页数：3

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