ROLE OF PHOSPHOLIPID LINING ON RESPIRATORY MUCUS CLEARANCE BY COUGH

被引:19
作者
GIROD, S
GALABERT, C
PIERROT, D
BOISSONNADE, MM
ZAHM, JM
BASZKIN, A
PUCHELLE, E
机构
[1] HOP RENEE SABRAN,F-83406 HYERES,FRANCE
[2] CNRS,URA 1218,F-92296 CHATENAY MALABRY,FRANCE
关键词
COUGH CLEARANCE; MUCUS ADHESION; MUCUS-MUCOSA INTERFACE; PHOSPHOLIPIDS; PHOSPHATIDYLGLYCEROL;
D O I
10.1152/jappl.1991.71.6.2262
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Phospholipid lining, present at the respiratory mucus-mucosa interface, may have an important role in the protective function of the airways by its adhesive properties and may also facilitate mucus transport. To mimic respiratory mucus-mucosa interface, monolayers of three different forms of phosphatidylglycerol (PG) have been deposited on glass slides by the Langmuir-Blodgett technique. Mucus adhesion and clearance by cough of mucus on these PG-coated or noncoated surfaces have been analyzed and compared, using frog respiratory mucus as "normal" mucus. Among the three PG types studied, the phosphatidylglycerol distearoyl, which is the phospholipid with the longest saturated fatty acid chain, was found to significantly improve the mucus cough clearance by decreasing the mucus work of adhesion compared with the noncoated surfaces. On the other hand, phosphatidylglycerol dipalmitoyl did not improve mucus cough clearance although it decreased mucus adhesion, and phosphatidylglycerol dioleyl did not improve either mucus cough clearance or mucus adhesion.
引用
收藏
页码:2262 / 2266
页数:5
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