SYNTHESES OF 2 TYROSINE SULFATE CONTAINING PEPTIDES, LEUCOSULFAKININ (LSK)-II AND CHOLECYSTOKININ (CCK)-12, USING THE O-PARA-(METHYLSULPHINYL)BENZYL SERINE FOR THE SELECTIVE SULFATION OF TYROSINE

被引：28

作者：

FUTAKI, S ^{[1
]}

TAIKE, T ^{[1
]}

AKITA, T ^{[1
]}

KITAGAWA, K ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN

来源：

TETRAHEDRON | 1992年 / 48卷 / 41期

关键词：

TYROSINE SULFATE CONTAINING PEPTIDE; SELECTIVE SULFATION ON TYROSINE; PARA-(METHYLSULPHINYL)BENZYL PROTECTING GROUP FOR SERINE; FMOC-SOLID PHASE PEPTIDE SYNTHESIS;

D O I：

10.1016/S0040-4020(01)81989-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach for the synthesis of tyrosine sulphate [Tyr(SO3H)]-containing peptides was developed. In this approach, trifluoroacetic acid stable O-p-(methylsulphinyl)-benzyl group was used as a key protecting group for serine to achieve the selective sulphation of tyrosine.

引用

页码：8899 / 8914

页数：16

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