CONJUGATED AZOALKENES .14. SYNTHESIS OF NEW 1-AMINO-PYRROLE AND 1,2-DIAMINO-PYRROLE DERIVATIVES BY REACTION OF SOME CONJUGATED AZOALKENES WITH ACTIVATED METHYLENE-COMPOUNDS RCH2AC AND RCH2CN (R = ARYL, HETEROARYL)

被引：17

作者：

ATTANASI, OA

LIAO, ZY

MCKILLOP, A

SANTEUSANIO, S

SERRAZANETTI, F

机构：

[1] BEIJING INST TECHNOL,DEPT CHEM ENGN,BEIJING 100081,PEOPLES R CHINA

[2] UNIV E ANGLIA,SCH CHEM SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 03期

关键词：

D O I：

10.1039/p19930000315

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Amino- and 1,2-diamino-pyrrole derivatives are obtained in high yield by reaction of conjugated azoalkenes with ketones and cyanides containing methylene groups further activated by a 4-nitrophenyl, 2-fluorophenyl, benzothiazol-2-yl or benzimidazol-2-yl group. In some cases the heterocycles can be prepared in a one flask procedure, while in others a two step sequence is required, namely, formation of the 1,4-conjugate adduct and then cyclization. Reaction of 2,4-dichloro- and 2,3,6-trichlorophenylacetonitrile with the azoalkenes gave the 1,4-conjugate adducts, but these could not be successfully cyclized.

引用

页码：315 / 320

页数：6

共 10 条

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