STRUCTURE OF (S)-(+)-IBUPROFEN

被引：66

作者：

FREER, AA ^{[1
]}

BUNYAN, JM ^{[1
]}

SHANKLAND, N ^{[1
]}

SHEEN, DB ^{[1
]}

机构：

[1] UNIV STRATHCLYDE,DEPT PHARM,GLASGOW G1 1XW,SCOTLAND

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1993年 / 49卷

关键词：

D O I：

10.1107/S0108270193000629

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(S)-(+)-Ibuprofen, alpha-methyl-4-(2-methylpropyl)-benzeneacetic acid, crystallizes with two molecules in the asymmetric unit to form a cyclic hydrogen-bonded dimer. Within the dimer each molecule shows subtle conformational differences via rotations about the acetic C(1)-C(2) and C(10)-C(11) bonds. Bond distances and angles for (S)-(+)-ibuprofen are in close agreement with those found for the structure of the racemic compound [McConnell (1974). Cryst. Struct. Commun. 3, 73-75].

引用

页码：1378 / 1380

页数：3