INCREASE IN TEMPERATURE ENHANCES SOLUBILITY OF DRUGS IN AQUEOUS-SOLUTIONS OF HYDROXYPROPYLCYCLODEXTRINS

被引：20

作者：

HOSHINO, T

UEKAMA, K

PITHA, J

机构：

[1] NIA,GRC,4940 EASTERN AVE,BALTIMORE,MD 21224

[2] KUMAMOTO UNIV,FAC PHARMACEUT SCI,KUMAMOTO 862,JAPAN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 98卷 / 1-3期

关键词：

HYDROXYPROPYLCYCLODEXTRIN; DRUG SOLUBILIZATION; DRUG PREPARATION; HYDROXYPROPYLCYCLODEXTRIN COMPLEX; TEMPERATURE EFFECT;

D O I：

10.1016/0378-5173(93)90063-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The solubilities of carbamazepine, dexamethasone, and griseofulvin in aqueous media were synergistically increased with increasing hydroxypropylcyclodextrin concentration and with increasing temperature. The results suggest that the increase in free drug concentration from solution heating counterbalances the simultaneously occurring dissociation of the drug-hydroxypropylcyclodextrin complexes. From a practical point of view, the results show that heating or heat-sterilization may be useful steps in the preparation of hydroxvpropylcyclodextrin-based pharmaceutical formulations.

引用

页码：239 / 242

页数：4

共 16 条

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