IDENTIFICATION OF A LYTIC-PHASE ORIGIN OF DNA-REPLICATION IN HUMAN HERPESVIRUS-6B STRAIN-Z29

被引：40

作者：

DEWHURST, S

DOLLARD, SC

PELLETT, PE

DAMBAUGH, TR

机构：

[1] UNIV ROCHESTER,CTR CANC,ROCHESTER,NY 14642

[2] CTR DIS CONTROL & PREVENT,NAT CTR INFECT DIS,ATLANTA,GA 30333

[3] DUPONT MERCK PHARMACEUT CO INC,EXPTL STN,WILMINGTON,DE 19880

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 12期

关键词：

D O I：

10.1128/JVI.67.12.7680-7683.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DNA sequences which have structural features suggestive of their functioning as an origin of lytic-phase DNA replication were previously identified in both human herpesvirus 6B strain Z29 [HHV-6B (Z29)] and in HHV-6A (U1102). Plasmid constructs containing the putative HHV-6B (Z29) oriLyt element were replicated after transfection into permissive T cells, when trans-acting factors were provided by HHV-6B (R-1) infection. By using this assay, the HHV-6B (Z29) oriLyt was mapped to a minimal region of approximately 400 bp which lies upstream of the gene that is homologous to herpes simplex virus UL29, a region that carries an origin in other betaherpesviruses and in some alphaherpesviruses.

引用

页码：7680 / 7683

页数：4

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