THE EFFECT OF POLYVINYLPYRROLIDONE AND HYDROXYPROPYL METHYLCELLULOSE ON HP-BETA-CD COMPLEXATION OF HYDROCORTISONE AND ITS PERMEABILITY THROUGH HAIRLESS MOUSE SKIN

被引：47

作者：

LOFTSSON, T

SIGUROARDOTTIR, AM

机构：

[1] Department of Pharmacy, University of Iceland, Reykjavik, P.O. Box 7210

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 1994年 / 2卷 / 04期

关键词：

COMPLEXATION; CYCLODEXTRINS; HYDROCORTISONE; PERMEABILITY; POLYMERS; SKIN;

D O I：

10.1016/0928-0987(94)90013-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of 2-hydroxypropyl-beta-cyclodextrin (HP beta CD), polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC) on the flux of hydrocortisone from an aqueous solution through hairless mouse skin was investigated in vitro. When the drug concentration was kept constant and the HP beta CD concentration was gradually increased, the flux through the skin was increased until all the drug had dissolved; after that the flux decreased with increasing HP beta CD concentration. PVP and HPMC increased the hydrocortisone-HP beta CD complexation resulting in increased solubilization of the drug. Also, the transdermal delivery of hydrocortisone could be increased by addition of a small amount of PVP or HPMC to an HP beta CD-containing vehicle.

引用

页码：297 / 301

页数：5

共 13 条

[1] COMBINATION EFFECTS OF O-CARBOXYMETHYL-O-ETHYL-BETA-CYCLODEXTRIN AND PENETRATION ENHANCER HPE-101 ON TRANSDERMAL DELIVERY OF PROSTAGLANDIN-E(1) IN HAIRLESS MICE [J].