THE DNA-BINDING PROTEIN PUL57 OF HUMAN CYTOMEGALOVIRUS IS A MAJOR TARGET ANTIGEN FOR THE IMMUNOGLOBULIN-M ANTIBODY-RESPONSE DURING ACUTE INFECTION

被引：23

作者：

VORNHAGEN, R

HINDERER, W

SONNEBORN, HH

BEIN, G

MATTER, L

THE, TH

JAHN, G

PLACHTER, B

机构：

[1] UNIV ERLANGEN NURNBERG, INST KLIN & MOLEK VIROL, D-91054 ERLANGEN, GERMANY

[2] UNIV LUBECK, INST IMMUNOL & TRANSFUS MED, D-23562 LUBECK, GERMANY

[3] BIOTEST AG, RES DEPT, D-63303 DREIEICH, GERMANY

[4] UNIV TUBINGEN, INST HYG, VIROL ABT, D-72076 TUBINGEN, GERMANY

[5] UNIV BERN, INST MED MIKROBIOL, CH-3010 BERN, SWITZERLAND

[6] UNIV GRONINGEN, DEPT CLIN IMMUNOL, 9700 AB GRONINGEN, NETHERLANDS

[7] UNIV GRONINGEN, RENAL TRANSPLANTAT UNIT, 9700 AB GRONINGEN, NETHERLANDS

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1995年 / 33卷 / 07期

关键词：

D O I：

10.1128/JCM.33.7.1927-1930.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A small polypeptide from pUL57 of human cytomegalovirus was identified as a major target for the immunoglobulin M antibody response. This antigen seems to be superior to antigenic fragments from pp150 and p52 in the identification of sera from acutely infected patients. It may therefore represent an essential antigen for recombinant immunoglobulin M antibody tests for human cytomegalovirus.

引用

页码：1927 / 1930

页数：4