MONOCYTE CHEMOTACTIC PROTEIN-1 IS RELEASED DURING LETHAL AND SUBLETHAL BACTEREMIA IN BABOONS

被引：46

作者：

JANSEN, PM

VANDAMME, J

PUT, W

DEJONG, IW

TAYLOR, FB

HACK, CE

机构：

[1] UNIV AMSTERDAM,CLIN & EXPTL IMMUNOL LAB,AMSTERDAM,NETHERLANDS

[2] FREE UNIV AMSTERDAM HOSP,DEPT INTERNAL MED,AMSTERDAM,NETHERLANDS

[3] UNIV LOUVAIN,REGA INST MED RES,LOUVAIN,BELGIUM

[4] OKLAHOMA MED RES FDN,OKLAHOMA CITY,OK

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 06期

关键词：

D O I：

10.1093/infdis/171.6.1640

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The chemokine monocyte chemotactic protein 1 (MCP-1) is a cytokine with chemotactic activity specific for mononuclear phagocytes. To investigate the possible involvement of MCP-1 in the pathogenesis of sepsis, its course was studied in baboons challenged intravenously with a sublethal or lethal dose of Escherichia coli. Levels of MCP-1 started to increase in both groups of animals 2 h after injection of E. coli, reaching peak levels 4 and 6 h after a sublethal (186 +/- 21 ng/mL) or a lethal (213 +/- 24 ng/mL) dose, respectively. Levels of MCP-1 correlated significantly with plasma levels of another chemokine, interleukin-8 (IL-8; r = .826, P < .001), suggesting that common stimuli mediate the release of both cytokines in this model.

引用

页码：1640 / 1642

页数：3

共 15 条

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