DAMSIN CYTOTOXIC PRINCIPLE OF AMBROSIA AMBROSIOIDES (CAV) PAYNE

被引：27

作者：

DOSKOTCH, RW

HUFFORD, CD

机构：

[1] College of Pharmacy, The Ohio State University, Columbus, Ohio

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 02期

关键词：

Chromatography; column; paper—separation; Cytotoxic principle—Ambrosia ambrosioides; Damsin—isolated; identified; IR spectrophotometry—identity; structure; Mass spectroscopy—identity; NMR spectroscopy—identity; UV spectrophotometry—identity;

D O I：

10.1002/jps.2600580208

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An alcoholic extract of the above ground parts of A. ambrosioides which showed significant activity against the KB cell culture was fractionated by solvent partitioning and chromatography on silicic acid. The active constituent was the pseudoguaianolide, damsin. A new sesquiterpene, damsinic acid, inactive against KB cells, was also isolated. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：186 / &

共 9 条

[1] THE CHEMISTRY OF AMBROSIA-MARITIMA L .1. THE ISOLATION AND PRELIMINARY CHARACTERIZATION OF AMBROSIN AND DAMSIN [J].