EFFECT OF INFUSIONS OF PLASMA AND OF SALINE ON RENAL RESPONSE TO WATER-LOADING IN SODIUM-DEPLETED DOGS

1. Infusion of 150 ml. of plasma to dogs acutely depleted of sodium chloride by peritoneal dialysis with glucose (5 g/100 ml.) does not restore their ability to respond by diuresis when given 2·5% body weight of water by mouth. 2. Infusion of 300 ml. of saline (0·73g NaCl/100 ml.) to these animals results in a brisk increase in urinary flow. 3. Infusion of 100 ml. of saline (0·73g NaCl/100 ml.) to sodium‐depleted dogs restores their ability to respond to a water‐load of 2·5% of body weight by diuresis. 4. The results are discussed and a tentative explanation put forward. © 1968 The Physiological Society