ANTICRYPTOCOCCAL ACTIVITY OF AMPHOTERICIN B-STIMULATED MACROPHAGES

被引：3

作者：

ASLANZADEH, J

MORMOL, JS

LITTLE, JR

机构：

[1] JEWISH HOSP,DEPT MED,216 S KINGSHIGHWAY,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,MED CTR,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1991年 / 13卷 / 04期

关键词：

D O I：

10.3109/08923979109019717

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Amphotericin B (AmB) and its methyl ester derivative (AME) are immunoadjuvants with macrophage stimulating properties. Cultures containing AmB and murine peritoneal macrophages showed synergistic anticryptococcal activity. The antifungal activity was associated with AmB-stimulated macrophages and with their culture supernatants. Photoinactivation of the residual AmB in the macrophage culture supernatant did not result in the loss of antifungal activity. AmB-stimulated macrophage culture supernatants inhibited the growth of C. neoformans in a dose responsive manner and the activity was destroyed by incubation at 100-degrees-C but not at 60-degrees-C.

引用

页码：465 / 483

页数：19

共 39 条

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