MODIFIED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF GANCICLOVIR IN PLASMA FROM PATIENTS WITH SEVERE RENAL IMPAIRMENT

被引：10

作者：

BOULIEU, R ^{[1
]}

BLEYZAC, N ^{[1
]}

FERRY, S ^{[1
]}

机构：

[1] HOP CARDIOVASC & PNEUMOL,SERV PHARMACEUT,F-69393 LYONS 03,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 571卷 / 1-2期

关键词：

D O I：

10.1016/0378-4347(91)80464-N

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Using the rapid and sensitive high-performance liquid chromatographic (HPLC) method previously described for the analysis of ganciclovir in plasma, we have observed an interfering peak which co-elutes with the peak of ganciclovir in plasma samples from heart-transplant patients with severe renal insufficiency. A slight modification of this method allows the separation of the two peaks. The modified HPLC method, presented in this paper, is suitable for the accurate determination of ganciclovir in plasma from patients with severe renal impairment.

引用

页码：331 / 333

页数：3

共 3 条

[1] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF GANCICLOVIR IN PLASMA [J].

BOULIEU, R ;

BLEYZAC, N ;

FERRY, S .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1991, 567 (02) :480-484

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