THE EFFECT OF PDGF ON THE HEALING OF FULL THICKNESS WOUNDS IN HAIRLESS GUINEA-PIGS

被引：14

作者：

HILL, E

TURNERBEATTY, M

GROTEWIEL, M

FOSHATHOMAS, S

COX, C

TURMAN, C

DREES, D

BAIRD, L

MARATEA, D

TUCKER, R

COUNTS, D

机构：

[1] MARION MERRELL DOW INC, POB 9627, KANSAS CITY, MO 64134 USA

[2] CREAT BIOMOLEC, HOPKINTON, MA 01748 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY | 1991年 / 100卷 / 02期

关键词：

D O I：

10.1016/0300-9629(91)90485-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Platelet-derived growth factor (PDGF), administered daily for 5 days and every other day for 9 additional days or the day of wounding and the following day, caused dose dependent (0.2, 1.0 or 5.0-mu-g PDGF/wound) increased granulation tissue. 2. The two day 5.0-mu-g treatment resulted in a 73% increase and the multi-day treatment resulted in a 52% increase of alkaline phosphatase activity three days after wounding. 3. Multi-day treatment resulted in significant increases in protein synthesis (132%), vimentin content (160%) and excised wound weight (76%) three days after wounding. 4. These results indicate that limited administration of PDGF alters wound healing although multiple applications provoke a more dramatic response.

引用

页码：365 / 370

页数：6

共 24 条

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