ENZYME ASSISTED PREPARATION OF ENANTIOMERICALLY PURE BETA-ADRENERGIC BLOCKERS .3. OPTICALLY-ACTIVE CHLOROHYDRIN DERIVATIVES AND THEIR CONVERSION

被引:45
作者
ADER, U [1 ]
SCHNEIDER, MP [1 ]
机构
[1] BERG UNIV GESAMTHSCH WUPPERTAL,FACHBEREICH 9,W-5600 WUPPERTAL 1,GERMANY
关键词
D O I
10.1016/S0957-4166(00)80256-6
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Optical active chlorohydrin derivatives 2a-m and 3a-m of both enantiomeric series were prepared via both enzymatic hydrolyses and acyltransfer reactions catalysed by a highly selective lipase from Pseudomonas sp.. The resulting building blocks were further transformed into the corresponding beta-blockers of high enantiomeric purity.
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页码:521 / 524
页数:4
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