ENZYME ASSISTED PREPARATION OF ENANTIOMERICALLY PURE BETA-ADRENERGIC BLOCKERS .3. OPTICALLY-ACTIVE CHLOROHYDRIN DERIVATIVES AND THEIR CONVERSION

被引：45

作者：

ADER, U ^{[1
]}

SCHNEIDER, MP ^{[1
]}

机构：

[1] BERG UNIV GESAMTHSCH WUPPERTAL,FACHBEREICH 9,W-5600 WUPPERTAL 1,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0957-4166(00)80256-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Optical active chlorohydrin derivatives 2a-m and 3a-m of both enantiomeric series were prepared via both enzymatic hydrolyses and acyltransfer reactions catalysed by a highly selective lipase from Pseudomonas sp.. The resulting building blocks were further transformed into the corresponding beta-blockers of high enantiomeric purity.

引用

页码：521 / 524

页数：4

共 34 条

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