IMMUNOGLOBULIN G3-SPECIFIC ANTIBODIES AS A MARKER FOR EARLY DIAGNOSIS OF HIV-INFECTION IN CHILDREN

被引:13
作者
ARICO, M
CASELLI, D
MARCONI, M
AVANZINI, MA
COLOMBO, A
PASINETTI, G
MACCABRUNI, A
RONDANELLI, EG
BURGIO, GR
机构
[1] UNIV PAVIA, IST RIC & CURA CARATTERE SCI, POLICLIN S MATTEO, DEPT PAEDIAT, I-27100 PAVIA, ITALY
[2] UNIV PAVIA, IST RIC & CURA CARATTERE, POLICLIN S MATTEO, DEPT INFECT DIS, I-27100 PAVIA, ITALY
[3] OSPED RIUNITI BERGAMO, DEPT NEONATAL, I-24100 BERGAMO, ITALY
关键词
HIV INFECTION; PEDIATRIC AIDS; IMMUNOGLOBULIN-G SUBCLASS;
D O I
10.1097/00002030-199111000-00005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Early diagnosis of HIV infection in the child of an HIV-infected mother may be difficult as HIV-specific immunoglobulin (Ig) G antibodies are transmitted to the fetus transplacentally. In an attempt to provide a new, simpler tool for early identification of HIV-infected children we analysed the HIV-specific IgG subclass pattern during the first year of life. One hundred and one samples were collected from 35 children born to HIV-seropositive mothers, among whom 18 seroreverted during follow-up and 17 were HIV-infected (two P1 and 15 P2 according to the Centers for Disease Control classification). Serum HIV-specific IgG3 was detectable at least in one sample in 26 out of 35 children. All 17 HIV-infected children showed persistently detectable specific IgG3, both with stable or progressive disease. Out of the 18 uninfected children who seroreverted during follow-up, nine were HIV-specific IgG3-negative when first tested and nine lost HIV-specific-IgG3 within 28 weeks after birth. The correlation of the serological results with clinical information and any other diagnostic tool on each child suggests that the clearance of specific-IgG3 antibodies heralds seroconversion in uninfected passive antibody-carrier children. This observation provides the basis for a new, simple and effective method for early diagnosis of HIV infection in children born to seropositive mothers.
引用
收藏
页码:1315 / 1318
页数:4
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