IS DEHYDROEPIANDROSTERONE AN ANTIOBESITY AGENT

被引：64

作者：

BERDANIER, CD ^{[1
]}

PARENTE, JA ^{[1
]}

MCINTOSH, MK ^{[1
]}

机构：

[1] UNIV N CAROLINA,DEPT FOODS & NUTR,GREENSBORO,NC 27412

来源：

FASEB JOURNAL | 1993年 / 7卷 / 05期

关键词：

DEHYDROPIANDROSTERONE; OBESITY; LIPOGENESIS; PEROXISOMES; MITOCHONDRIAL RESPIRATION; ENERGY BALANCE;

D O I：

10.1096/fasebj.7.5.8462783

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The steroid hormone intermediate, DHEA, has been proposed as a therapeutic agent for the treatment of obesity. Its effects on lipogenesis, substrate cycling, peroxisome proliferation, mitochondrial respiration, protein synthesis, and thyroid hormone function have been reported. The results of these studies suggest that the antiobesity function of DHEA is not simply one of inhibiting fat synthesis and deposition but is one of affecting a number of pathways that contribute to the maintenance of the isoenergetic state rather than the promotion of positive energy balance.

引用

页码：414 / 419

页数：6

共 65 条

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