SOLID-STATE DISPERSIONS EMPLOYING URETHANE

The dissolution rates of a number of drug‐urethan solidstate dispersion systems were studied. A marked enhancement of the initial dissolution rates of several poorly water‐soluble drugs was found when they were incorporated into a urethan matrix by heat fusion. These differences were considerable when pure substances such as griseofulvin, hydrocortisone, chloramphenicol, and acetaminophen were compared to the urethan‐drug solid dispersion. Physical mixtures of the medicinal agents with urethan also gave a marked increase in the amount of drug in solution, with the value in most cases being over one‐half that of the solid‐state dispersion. Data are given, comparing ultrafiltration with samples filtered through cotton, regarding drug content remaining in solution. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company