A CRITICAL ANALYSIS OF A CAPSULE DISSOLUTION TEST

被引：32

作者：

WITHEY, RJ

MAINVILLE, CA

机构：

[1] Research Laboratories, Food and Drug Directorate, Department of National Health and Welfare, Ottawa

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 09期

关键词：

Capsule dissolution testing–methodology; Chloramphenicol capsules–dissolution; Diagram–dissolution apparatus; Lactose effect–capsule dissolution rates; Particle size effect–capsule dissolution rates; UV spectrophotometry–analysis;

D O I：

10.1002/jps.2600580918

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A suitably modified USP disintegration apparatus has been used to obtain dissolution rate data for chloramphenicol capsules. Differences between various commercial and laboratory formulations of this drug were reflected in their dissolution profiles. Several shortcomings of this apparatus are described. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

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页码：1120 / +

页数：1

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