A CRITICAL ANALYSIS OF A CAPSULE DISSOLUTION TEST

被引：32

作者：

WITHEY, RJ

MAINVILLE, CA

机构：

[1] Research Laboratories, Food and Drug Directorate, Department of National Health and Welfare, Ottawa

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 09期

关键词：

Capsule dissolution testing–methodology; Chloramphenicol capsules–dissolution; Diagram–dissolution apparatus; Lactose effect–capsule dissolution rates; Particle size effect–capsule dissolution rates; UV spectrophotometry–analysis;

D O I：

10.1002/jps.2600580918

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A suitably modified USP disintegration apparatus has been used to obtain dissolution rate data for chloramphenicol capsules. Differences between various commercial and laboratory formulations of this drug were reflected in their dissolution profiles. Several shortcomings of this apparatus are described. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

收藏

页码：1120 / +

页数：1

相关论文

共 20 条

[1] EVALUATION OF PHYSICAL AND PHARMACEUTICAL FACTORS INVOLVED IN DRUG RELEASE AND AVAILABILITY FROM CHLORAMPHENICOL CAPSULES [J].

AGUIAR, AJ ;

WHEELER, LM ;

FUSARI, S ;

ZELMER, JE .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (11) :1844-&

[2] APPLICATION OF ANALOGUE COMPUTER TO PHARMACOKINETIC AND BIOPHARMACEUTICAL STUDIES WITH AMPHETAMINE-TYPE COMPOUNDS [J].

BECKETT, AH ;

TUCKER, GT .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1968, 20 (03) :174-&

[3] DISSOLUTION APPARATUS WITH MULTIPLE TESTING STATIONS [J].

CASTELLO, RA ;

JELLINEK, G ;

KONIECZNY, JM ;

KWAN, KC ;

TOBERMAN, RO .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (03) :485-+

[4]

COOK D, 1966, CAN J PHARM SCI, V1, P69

[5] RELATIONSHIP BETWEEN IN VITRO DISSOLUTION RATES AND SOLUBILITIES OF NUMEROUS COMPOUNDS REPRESENTATIVE OF VARIOUS CHEMICAL SPECIES [J].

HAMLIN, WE ;

NORTHAM, JI ;

WAGNER, JG .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (11) :1651-&

[6] Dependence of reaction velocity upon surface and agitation I - Theoretical consideration [J].

Hixson, AW ;

Crowell, JH .

INDUSTRIAL AND ENGINEERING CHEMISTRY, 1931, 23 :923-931

[7] Agitation - Mass transfer coefficients in liquid-solid agitation systems [J].

Hixson, AW ;

Baum, SJ .

INDUSTRIAL AND ENGINEERING CHEMISTRY, 1941, 33 :478-485

[8] EFFECT OF CERTAIN TABLET FORMULATION FACTORS ON DISSOLUTION RATE OF ACTIVE INGREDIENT .3. TABLET LUBRICANTS [J].

LEVY, G ;

GUMTOW, RH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (12) :1139-+

[9] INTER- + INTRASUBJECT VARIATIONS IN DRUG ABSORPTION KINETICS [J].

LEVY, G ;

HOLLISTER, LE .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (12) :1446-&

[10] INTERDEPENDENCE OF PHYSIOLOGICAL SURFACTANT AND DRUG PARTICLE SIZE ON DISSOLUTION BEHAVIOR OF WATER-INSOLUBLE DRUGS [J].

LIN, SL ;

MENIG, J ;

LACHMAN, L .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (12) :2143-&