ANGIOTENSIN-II STIMULATES ANGIOGENESIS IN THE CHORIOALLANTOIC MEMBRANE OF THE CHICK-EMBRYO

被引：184

作者：

LENOBLE, FAC

HEKKING, JWM

VANSTRAATEN, HWM

SLAAF, DW

BOUDIER, HAJS

机构：

[1] STATE UNIV LIMBURG,DEPT PHARMACOL,POB 616,6200 MD MAASTRICHT,NETHERLANDS

[2] STATE UNIV LIMBURG,DEPT ANAT EMBRYOL,6200 MD MAASTRICHT,NETHERLANDS

[3] STATE UNIV LIMBURG,DEPT BIOPHYS,6200 MD MAASTRICHT,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 195卷 / 02期

关键词：

ANGIOGENESIS; ANGIOTENSIN-II; HYPERTENSION; CHORIOALLANTOIC MEMBRANE; BLOOD VESSELS;

D O I：

10.1016/0014-2999(91)90552-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Angiotensin II was applied daily in doses of 67 or 670 ng to a section of the chick embryo chorio-allantoic membrane from day 7 to day 14 after fertilization of the eggs. During this one-week period, it caused a significant, dose-dependent increase in the vascular density index. The increase obtained with 670 ng daily was comparable to that after daily administration of 1.7-mu-g adenosine, a known stimulator of angiogenesis. The data suggest a possible role for angiotensin II as a mediator of vascular growth.

引用

页码：305 / 306

页数：2

共 10 条

[1] METABOLISM AND PRODUCTION OF ANGIOTENSIN-I IN DIFFERENT VASCULAR BEDS IN SUBJECTS WITH HYPERTENSION [J].