AN AMINO-PROXIMAL DOMAIN REQUIRED FOR THE LOCALIZATION OF FTSQ IN THE CYTOPLASMIC MEMBRANE, AND FOR ITS BIOLOGICAL FUNCTION IN ESCHERICHIA-COLI

被引:17
作者
DOPAZO, A [1 ]
PALACIOS, P [1 ]
SANCHEZ, M [1 ]
PLA, J [1 ]
VICENTE, M [1 ]
机构
[1] CSIC,CTR INVEST BIOL,C VELAZQUEZ 144,E-28006 MADRID,SPAIN
关键词
D O I
10.1111/j.1365-2958.1992.tb01520.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The location of FtsQ, an Escherichia coli protein essential for cell division, is, under physiological conditions, in the cytoplasmic membrane facing towards the periplasmic space. An amino-proximal hydrophobic domain is required for FtsQ to reach its location and for its activity in the cell. Overexpression of modified forms of FtsQ is deleterious for the cell.
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页码:715 / 722
页数:8
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