INFLUENCE OF AGING, ENVIRONMENTAL ANTIGENS, AND DIETARY RESTRICTION ON EXPRESSION OF LYMPHOCYTE SUBSETS IN GERM-FREE AND CONVENTIONAL LOBUND-WISTAR RATS

被引：13

作者：

GILMANSACHS, A ^{[1
]}

KIM, YB ^{[1
]}

POLLARD, M ^{[1
]}

SNYDER, DL ^{[1
]}

机构：

[1] UNIV NOTRE DAME, LOBUND LAB, NOTRE DAME, IN 46556 USA

来源：

JOURNALS OF GERONTOLOGY | 1991年 / 46卷 / 03期

关键词：

D O I：

10.1093/geronj/46.3.B101

中图分类号：

R4 [临床医学]; R592 [老年病学];

学科分类号：

1002 ; 100203 ; 100602 ;

摘要：

Lymphocyte subsets from four groups of Lobund-Wistar (L-W) rats were quantitated to determine the influence of diet restriction (DR) and exposure to environmental antigens on the development of these cells. The following effects were found from 6 to 30 months of age: The number of Ts/c and Ts cells were higher in germ-free (GF) vs conventional (CV) rats, whereas B-cell numbers were lower. W3/13 T cells, Ts, and NK cell numbers were higher in DR vs full-fed rats, whereas B-cell numbers were lower. OX19 and W3/13 T cell numbers decreased from 6 months to 30 months in each group, whereas NK cell numbers increased. Also, OX6+ B cell numbers increased with age, and Ts/c numbers decreased. These data may reflect a relationship between enhanced T-cell function and the extended life span and lower tumor incidence observed in DR L-W rats.

引用

页码：B101 / B106

页数：6

共 29 条

[1]

BABCOCK GF, 1987, DIAGN CLIN IMMUNOL, V5, P175

[2]

EBERLY KW, 1989, DIETARY RESTRICTION, P105

[3]

FERNANDES G, 1976, J IMMUNOL, V116, P782

[4] SIMPLE AND RAPID MEASUREMENT OF HUMAN LYMPHOCYTES-T AND THEIR SUBCLASSES IN PERIPHERAL-BLOOD [J].

HOFFMAN, RA ;

KUNG, PC ;

HANSEN, WP ;

GOLDSTEIN, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (08) :4914-4917

[5] INFLUENCE OF EARLY OR LATE DIETARY RESTRICTION ON LIFE-SPAN AND IMMUNOLOGICAL PARAMETERS IN MRL MP-LPR LPR MICE [J].

KUBO, C ;

DAY, NK ;

GOOD, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (18) :5831-5835

[6] CALORIE SOURCE, CALORIE RESTRICTION, IMMUNITY AND AGING OF (NZB/NZW)F1 MICE [J].

KUBO, C ;

JOHNSON, BC ;

DAY, NK ;

GOOD, RA .

JOURNAL OF NUTRITION, 1984, 114 (10) :1884-1899

[7]

MAGE RG, 1986, HDB EXPT IMMUNOLOGY

[8]

Makinodan T, 1980, Adv Immunol, V29, P287, DOI 10.1016/S0065-2776(08)60047-4

[9] FUNCTIONS OF RAT LYMPHOCYTE-T SUBSETS ISOLATED BY MEANS OF MONOCLONAL-ANTIBODIES [J].

MASON, DW ;

ARTHUR, RP ;

DALLMAN, MJ ;

GREEN, JR ;

SPICKETT, GP ;

THOMAS, ML .

IMMUNOLOGICAL REVIEWS, 1983, 74 :57-82

[10] FOOD RESTRICTION IN RODENTS - AN EVALUATION OF ITS ROLE IN THE STUDY OF AGING [J].

MASORO, EJ .

JOURNALS OF GERONTOLOGY, 1988, 43 (03) :B59-B64

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