CORTICAL SOMATOSENSORY MAGNETIC RESPONSES IN MULTIPLE-SCLEROSIS

被引：21

作者：

KARHU, J ^{[1
]}

HARI, R ^{[1
]}

MAKELA, JP ^{[1
]}

HUTTUNEN, J ^{[1
]}

KNUUTILA, J ^{[1
]}

机构：

[1] HELSINKI UNIV, CENT HOSP, DEPT NEUROL, SF-00290 HELSINKI, FINLAND

来源：

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1992年 / 83卷 / 03期

基金：

芬兰科学院;

关键词：

MULTIPLE SCLEROSIS; EVOKED RESPONSES; MAGNETOENCEPHALOGRAPHY; MEDIAN NERVE; ULNAR NERVE; PRIMARY SOMATOSENSORY CORTEX;

D O I：

10.1016/0013-4694(92)90144-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Somatosensory evoked magnetic fields (SEFs) to contralateral median and ulnar nerve stimulation were analyzed in 10 patients with multiple sclerosis and in 8 healthy controls. SEFs were recorded with a 24-channel SQUID gradiometer over both hemispheres. Seven patients showed abnormally large-amplitude SEF deflections at 60-80 msec; 5 of them had multiple lesions around lateral ventricles in magnetic resonance imaging. In 2 patients with plaques at the level of 3rd and 4th ventricles and medulla, the 30 msec responses were enlarged. The equivalent sources of 20 msec and 30-80 msec responses were in the primary hand sensorimotor cortex both in patients and in control subjects. The results suggest that early and middle-latency SEFs reflect parallel processing of somatosensory input. Recording of middle-latency evoked responses, electric or magnetic, may give additional information about the somatosensory function in multiple sclerosis.

引用

页码：192 / 200

页数：9

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