INHIBITION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINE KINASE-ACTIVITY BY LEFLUNOMIDE

被引：154

作者：

MATTAR, T

KOCHHAR, K

BARTLETT, R

BREMER, EG

FINNEGAN, A

机构：

[1] UNIV MAINZ,DEPT IMMUNOL,W-6500 MAINZ,GERMANY

[2] HOECHST AG,W-6200 WIESBADEN,GERMANY

[3] RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT IMMUNOL MICROBIOL,CHICAGO,IL 60612

[4] RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT MED,CHICAGO,IL 60612

来源：

FEBS LETTERS | 1993年 / 334卷 / 02期

关键词：

EPIDERMAL GROWTH FACTOR RECEPTOR; TYROSINE-SPECIFIC KINASE; LEFLUNOMIDE; HUMAN FORESKIN FIBROBLAST CELL;

D O I：

10.1016/0014-5793(93)81704-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The active metabolite of leflunomide, A77 1726 inhibits the proliferation of a variety of mammalian cell lines in culture. Epidermal growth factor (EGF)-dependent proliferation is inhibited by A77 1726 at an effective dose of 30-40 muM. A77 1726 appears to directly inhibit the EGF receptor tyrosine-specific kinase activity both in intact cells and purified EGF receptors at the same effective dose. These data suggest that leflunomide inhibits cellular proliferation by the inhibition of tyrosine-specific kinase activities.

引用

页码：161 / 164

页数：4

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