THE ANTIMENINGOCOCCAL VACCINE VAMENGOC B-C INDUCED POOR SERUM AND SALIVARY ANTIBODY-RESPONSE IN YOUNG BRAZILIAN CHILDREN

被引：7

作者：

CARBONARE, SB

ARSLANIAN, C

SILVA, MLM

FARHAT, CK

CARNEIROSAMPAIO, MMS

机构：

[1] UNIV SAO PAULO,INST CIENCIAS BIOMED,DEPT IMUNOL,BR-05508900 SAO PAULO,BRAZIL

[2] FED UNIV SAO PAULO,SCH MED,DEPT PEDIAT,SAO PAULO,BRAZIL

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 1995年 / 14卷 / 09期

关键词：

MENINGITIS; NEISSERIA MENINGITIDIS; ANTIMENINGOCOCCAL VACCINE; BACTERIAL ADHESION; SALIVARY ANTIBODIES; SECRETORY ANTIBODIES; SERUM ANTIBODIES;

D O I：

10.1097/00006454-199509000-00013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 1989 about 2.3 million Brazilian children received the antimeningococcal vaccine VAMEN-GOC B-C (Havana, Cuba). We evaluated the serum and secretory immune response of vaccinated children by enzyme-linked immunosorbent assay with outer membrane complex antigens. Western blotting and bacterial adherence inhibition assays with human buccal epithelial cells were performed with some of the samples. Serum and salivary antibody concentrations to Neisseria meningitidis Group B of vaccinated children <4 years old were not significantly higher than those of nonvaccinated children, as observed in convalescing patients used as positive controls. Older children (4 to 6 years old) presented a slight increase in antibody OD indexes. Sera and saliva from vaccinated children showed a weak reaction with meningococcal antigen by Western blotting and were unable to inhibit significantly the adherence of N. meningitidis B to buccal epithelial cells. These data suggest that this vaccine induced a poor serum and salivary antibody response in the population studied.

引用

页码：797 / 803

页数：7

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