CLONING OF THE CDNA AND THE GENOMIC DNA OF THE MOUSE ANGIOTENSIN-II TYPE-2 RECEPTOR

被引：40

作者：

ICHIKI, T ^{[1
]}

HEROLD, CL ^{[1
]}

KAMBAYASHI, Y ^{[1
]}

BARDHAN, S ^{[1
]}

INAGAMI, T ^{[1
]}

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1994年 / 1189卷 / 02期

关键词：

ANGIOTENSIN II; TYPE; 2; RECEPTOR; CDNA; GENOMIC DNA SEQUENCE; (MOUSE);

D O I：

10.1016/0005-2736(94)90072-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Of the two major isoforms of the angiotensin II receptors, type 1 (AT(1)) and type 2 (AT(2)), little is known about the structure and features of AT(2). We cloned a mouse AT(2) cDNA from a mouse fetus cDNA library and an AT(2) genomic DNA from a 129SV mouse genomic DNA library. The amino acid sequence of the mouse AT(2) (363 residues) deduced from a mouse cDNA clone showed seven membrane-spanning domains. Amino acid identity of the mouse AT(2) with mouse AT(1) is 37%, and 98% with rat AT(2). The genomic DNA (4.4 kb) contained three exons and two introns and the entire coding region was contained in the third exon.

引用

页码：247 / 250

页数：4

共 14 条

[1] ANGIOTENSIN-II AT2 RECEPTORS DO NOT INTERACT WITH GUANINE-NUCLEOTIDE BINDING-PROTEINS
BOTTARI, SP
TAYLOR, V
KING, IN
BOGDAL, Y
WHITEBREAD, S
DEGASPARO, M
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1991, 207 (02): : 157 - 163
[2] IDENTIFICATION OF ANGIOTENSIN-II RECEPTOR SUBTYPES
CHIU, AT
HERBLIN, WF
MCCALL, DE
ARDECKY, RJ
CARINI, DJ
DUNCIA, JV
PEASE, LJ
WONG, PC
WEXLER, RR
JOHNSON, AL
TIMMERMANS, PBMWM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (01) : 196 - 203
[3] DUDLEY DT, 1991, MOL PHARMACOL, V40, P360
[4] DUDLEY DT, 1990, MOL PHARMACOL, V38, P370
[5] EXPRESSION OF AT2-RECEPTORS IN THE DEVELOPING RAT FETUS
GRADY, EF
SECHI, LA
GRIFFIN, CA
SCHAMBELAN, M
KALINYAK, JE
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (03) : 921 - 933
[6] KAMBAYASHI Y, 1993, IN PRESS J BIOL CHEM
[7] CHANGES IN SKIN ANGIOTENSIN-II RECEPTORS IN RATS DURING WOUND-HEALING
KIMURA, B
SUMNERS, C
PHILLIPS, MI
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 187 (02) : 1083 - 1090
[8] ISOLATION OF A CDNA-ENCODING THE VASCULAR TYPE-1 ANGIOTENSIN-II RECEPTOR
MURPHY, TJ
ALEXANDER, RW
GRIENDLING, KK
RUNGE, MS
BERNSTEIN, KE
[J]. NATURE, 1991, 351 (6323) : 233 - 236
[9] BIOCHEMICAL-PROPERTIES OF THE OVARIAN GRANULOSA-CELL TYPE-2-ANGIOTENSIN-II RECEPTOR
PUCELL, AG
HODGES, JC
SEN, I
BUMPUS, FM
HUSAIN, A
[J]. ENDOCRINOLOGY, 1991, 128 (04) : 1947 - 1959
[10] CLONING, CHARACTERIZATION, AND EXPRESSION OF 2 ANGIOTENSIN RECEPTOR (AT-1) ISOFORMS FROM THE MOUSE GENOME
SASAMURA, H
HEIN, L
KRIEGER, JE
PRATT, RE
KOBILKA, BK
DZAU, VJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 185 (01) : 253 - 259

← 1 2 →